Endocrine Abstracts

Background: Obesity is associated with cardiac structural changes, repolarization abnormalities and rhythm disorders. The aim of this systematic review is to provide an overview of the literature on obesity, cardiac arrhythmias, obesity associated ECG abnormalities and the effects of bariatric and metabolic surgery.Methods: A systematic search on the effects of obesity and bariatric surgery on cardiac arrhythmias and associated ECG abnormalities was cond...

Background: Insulin-induced hypoglycemia has been demonstrated to prolong the corrected QT (QTc) interval. Prolongation of QTc interval, especially in diabetic patients using insulin, can cause fatal ventricular arrhythmias. The aim of this study was to evaluate the effects of metoprolol, diltiazem and pilocarpine on hypoglycemia-induced QTc prolongation.Methods: Thirty rats were randomly distributed into the following five groups: Group 1 (1 ml/kg salin...

Objective: To compare the impact of 4 surgical procedures (mini gastric bypass [MGB], sleeve gastrectomy [SG], ileal transposition [IT], and transit bipartition [TB]) versus medical management on gut peptide secretion, beta cell function, and resolution of hyperglycaemia in type 2 diabetes (T2DM).Research design and methodsA mixed-meal tolerance test (MMTT) was administered 6–24 months after each surgical procedure (mini gast...

Background: One of the most important complications of the One Anastomosis Gastric Bypass (OAGB) is enterobilioacid reflux (EBAR). We report the concept of the Long Pouch Roux-en Y Gastric Bypass (LPRYGB) meaning a Roux-en-Y with a long pouch and a 100 cm alimentary limb to avoid EBAR, with a long biliopancreatic limb to increase metabolic effects.Methods: A total of 300 LPRYGB cases in a four-year period, with a 90% follow up rate, were analyzed. Anthro...

Background: Several studies showed that there is a relationship between vitamin and mineral status and muscle strength. In particular this is the case for handgrip strength (HS) and vitamin D deficiency. In bariatric surgery there is a risk of decrease in muscle strength after surgery and also vitamin and mineral deficiencies are not uncommon. The aim of this study is to assess the effect of low vitamin 25 (OH) cholecalciferol levels, high dose cholecalciferol supplementation ...

Background: Type 2 diabetes mellitus became a global problem during recent decades, and unfortunately medical treatment fails to provide adequate control in many obese diabetics. We aimed to perform a prospective comparative cohort study to investigate how soon patients achieve glycemic control after three different surgical options (sleeve gastrectomy (SG), mini-gastric bypass (MGB), diverted sleeve gastrectomy with ileal transposition (DSIT)) within the first 30 days postope...

Background: Medical treatment fails to provide adequate control for many obese patients with type 2 diabetes mellitus (T2DM). A comparative observational study of bariatric procedures was performed to investigate the time at which patients achieve glycemic control within the first 30 postoperative days following sleeve gastrectomy (SG), mini-gastric bypass (MGB), and diverted sleeve gastrectomy with ileal transposition (DSIT).Methods: Included patients h...